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5 Cologne startups that investors should know

#StartupsToWatch

The current Cologne Masterclass shows once again how diverse the Cologne startup ecosystem is. The range of nominated companies is wide – this is demonstrated by H2ALL, Sizeless, Leadrealizer, Vivalyx and Kumo. Investors should take a close look at these startups.

The current Cologne Masterclass shows once again how diverse the Cologne startup ecosystem is. The range of nominated companies is wide – this is demonstrated by H2ALL, Sizeless, Leadrealizer, Vivalyx and Kumo. Investors should take a close look at these startups.

With the Cologne Masterclass, KölnBusiness and its partners annually honor selected startups from the region and make them more visible to investors. The startups are nominated from the programs of local ecosystem players and receive marketing support as part of the master class as well as the chance to pitch to investors at the Matching Day.

The Cologne Masterclass 2025 shows once again how diverse and innovative the Cologne startup ecosystem is. From digital health to communication solutions to tech and software developments – the range of nominated companies is wide. The highlight of the Cologne Masterclass 2025 will follow on January 29, 2026 with the Matching Day. Here is a look at the first five of the 15 startups that made it into the Cologne Masterclass 2025.

H2ALL – Planning tool for the decarbonization of industry
The Cologne startup H2ALL has developed a digital solution that maps the entire planning process of hydrogen projects – from the initial project evaluation and site-specific simulation to the creation of approval and safety documentation. H2ALL is thus significantly driving forward the decarbonization of the industry. The startup’s goal: Use its planning platform to accelerate the ramp-up of the green hydrogen economy – and become the European standard tool for hydrogen projects.

Sizeless – the children’s shoe from Cologne that grows with you
The Cologne startup Sizeless has developed a size-adjustable children’s shoe that accompanies children through several growth phases. The approach aims to use less resources through a longer period of use – and a better fit that should support the health of children’s feet. It was developed at the German Sport University Cologne – based on extensive orthopedic and biomechanical expertise.

Leadrealizer – AI-powered done-for-you solution for B2B cold calling
Leadrealizer offers companies a done-for-you solution for B2B cold calling and lead generation – with the aim of making new customer acquisition faster and more efficient. The Cologne startup takes care of the entire process: from target group research to the personalized approach of potential customers to arranging appointments. AI technologies and common sales tools are used.

Vivalyx – Innovation for more efficient organ cooling during transplants
Vivalyx is active in the field of medical technology and is developing a solution to optimize organ cooling during transplants. By using a patented, synthetic blood substitute, the cooling process is intended to become more efficient – with the aim of better maintaining the quality of transplantable organs during transport and storage.

Kumo – AI solution for securing implicit knowledge
With its Brainbridge program, Kumo has developed an AI-supported solution to capture, structure and make accessible implicit knowledge in companies. Through dynamic language interviews, employees’ knowledge is systematically documented – and is thus permanently retained by the company even during personnel changes.

Get started in Cologne – #Koelnbusiness

In our focus on Cologne, we highlight the dynamic startup ecosystem of the Rhine metropolis. What are the conditions for founders, what investments flow into innovative ideas and which startups provide new impetus? Around 800 startups have already chosen Cologne as their location – supported by a lively start-up scene, a strong investor landscape and numerous coworking spaces, trade fairs and networking events. As a central contact point for the startup and innovation scene, the Cologne Business Economic Development Agency strengthens the framework conditions for founders, connects them with investors and offers targeted support. This section is supported by KölnBusiness. #Koelnbusiness on LinkedIn, Facebook and Instagram.

CologneBusiness
Photo (above): Shutterstock



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